COVID-19 Response: Local Logistics     National Effort

Mon1 constitutes a novel node in the brain-gonad axis that is essential for female germline maturation. [Transgenic Fly Facility]

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COVID-19 Response: Local Logistics     National Effort

TitleMon1 constitutes a novel node in the brain-gonad axis that is essential for female germline maturation. [Transgenic Fly Facility]
Publication TypeJournal Article
Year of Publication2019
AuthorsDhiman N, Shweta K, Tendulkar S, Deshpande G, Ratnaparkhi GS, Ratnaparkhi A
JournalDevelopment
Volume146
Issue13
Date Published2019 Jul 10
ISSN1477-9129
Abstract

Monensin-sensitive 1 (Mon1) is an endocytic regulator that participates in the conversion of Rab5-positive early endosomes to Rab7-positive late endosomes. In , loss of leads to sterility as the mutant females have extremely small ovaries with complete absence of late stage egg chambers - a phenotype reminiscent of mutations in the insulin pathway genes. Here, we show that expression of many insulin-like peptides (ILPs) is reduced in mutants and feeding adults an insulin-rich diet can rescue the ovarian defects. Surprisingly, however, functions in the tyramine/octopaminergic neurons (OPNs) and not in the ovaries or the insulin-producing cells (IPCs). Consistently, knockdown of in only the OPNs is sufficient to mimic the ovarian phenotype, while expression of the gene in the OPNs alone can 'rescue' the mutant defect. Last, we have identified and as critical targets of This study thus identifies as a novel molecular player in the brain-gonad axis and underscores the significance of inter-organ systemic communication during development.

DOI10.1242/dev.166504
Alternate JournalDevelopment
PubMed ID31292144