@article {8125,
	title = {Conformationally restricted, dipeptide-based, self-assembled nanoparticles for efficient vancomycin delivery. [C-CAMP BIG Grantee/Startup]},
	journal = {Nanomedicine (Lond)},
	year = {2023},
	month = {2023 Jan 16},
	type = {Journal Article},
	abstract = {<p>Emergence of vancomycin (Van) resistance, and usage of its higher dose and short half-life are posing a serious concern. Slow and sustained release of Van using a nanodelivery system may overcome these problems. Arginine-α,β-dehydrophenylalanine (RΔF) was synthesized using solution-phase synthesis which self-assembled into nanospheres. Van was entrapped in the nanoparticles (NPs). and efficacy of Van-RΔF was determined using broth microdilution and the mouse thigh infection model, respectively. Van-RΔF NPs efficiently inhibited bacterial growth (), while Van alone showed limited growth inhibition in . Intravenous administration of Van-RΔF in mice with bacterial thigh infection showed enhanced efficacy (double) compared with Van alone, which indicates its high potential for further development.</p>
},
	keywords = {antibiotic delivery, nanostructures, self-assembly, sustained release, ultrashort peptides},
	issn = {1748-6963},
	doi = {10.2217/nnm-2022-0144},
	url = {https://www.futuremedicine.com/doi/abs/10.2217/nnm-2022-0144},
	author = {Yadav, Nitin and Kumar, Utkarsh and Chauhan, Virander Singh}
}
@article {7323,
	title = {Ultrashort Peptide-Based Hydrogel for the Healing of Critical Bone Defects in Rabbits [C-CAMP BIG Grantee/Startup]},
	journal = {ACS Appl Mater Interfaces},
	year = {2022},
	month = {2022 Nov 19},
	abstract = {<p>The use of hydrogels as scaffolds for three-dimensional (3D) cell growth is an active area of research in tissue engineering. Herein, we report the self-assembly of an ultrashort peptide, a tetrapeptide, Asp-Leu-IIe-IIe, the shortest peptide sequence from a highly fibrillogenic protein TDP-43, into the hydrogel. The hydrogel was mechanically strong and highly stable, with storage modulus values in MPa ranges. The hydrogel supported the proliferation and successful differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) in its matrix as assessed by cell viability, calcium deposition, alkaline phosphatase (ALP) activity, and the expression of osteogenic marker gene studies. To check whether the hydrogel supports 3D growth and regeneration in conditions, a rabbit critical bone defect model was used. Micro-computed tomography (CT) and X-ray analysis demonstrated the formation of mineralized neobone in the defect areas, with significantly higher bone mineralization and relative bone densities in animals treated with the peptide hydrogel compared to nontreated and matrigel treatment groups. The ultrashort peptide-based hydrogel developed in this work holds great potential for its further development as tissue regeneration and/or engineering scaffolds.</p>
},
	issn = {1944-8252},
	doi = {10.1021/acsami.2c18733},
	author = {Yadav, Nitin and Kumar, Utkarsh and Roopmani, Purandhi and Krishnan, Uma Maheswari and Sethuraman, Swaminathan and Chauhan, Meenakshi K and Chauhan, Virander S}
}
