COVID-19 Response: Local Logistics     National Effort

Role of Homothorax in region specific regulation of Deformed in embryonic neuroblasts.

You are here

COVID-19 Response: Local Logistics     National Effort

TitleRole of Homothorax in region specific regulation of Deformed in embryonic neuroblasts.
Publication TypeJournal Article
Year of Publication2015
AuthorsKumar R, Chotaliya M, Vuppala S, Auradkar A, Palasamudrum K, Joshi R
JournalMech Dev
Volume138 Pt 2
Pagination190-7
Date Published2015 Nov
ISSN1872-6356
KeywordsAnimals, Central Nervous System, Drosophila, Drosophila Proteins, Enhancer Elements, Genetic, Gene Expression Regulation, Developmental, Genes, Homeobox, Homeodomain Proteins, Neural Stem Cells, Organogenesis
Abstract

The expression and regulation of Hox genes in developing central nervous system (CNS) lack important details like specific cell types where Hox genes are expressed and the transcriptional regulatory players involved in these cells. In this study we have investigated the expression and regulation of Drosophila Hox gene Deformed (Dfd) in specific cell types of embryonic CNS. Using Dfd neural autoregulatory enhancer we find that Dfd autoregulates itself in cells of mandibular neuromere. We have also investigated the role of a Hox cofactor Homothorax (Hth) for its role in regulating Dfd expression in CNS. We find that Hth exhibits a region specific role in controlling the expression of Dfd, but has no direct role in mandibular Dfd neural autoregulatory circuit. Our results also suggest that homeodomain of Hth is not required for regulating Dfd expression in embryonic CNS.

DOI10.1016/j.mod.2015.09.003
Alternate JournalMech. Dev.
PubMed ID26409112
PubMed Central IDPMC4678145