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TECHNOLOGY

The invention discloses a process of preparing nanoparticles of a stable delivery complex comprising conformationally-restricted amino acid and a charged amino acid for delivering small molecule and nucleic acid molecules.

The existing drug delivery vehicle has limitations including poor bioavailability, instability in the circulation, inadequate tissue distribution, and potential toxicity during long-term administration. The current disclosure provides a highly stable dual delivery complex that simultaneously delivers two different cargo molecules to a target site without affecting the bioavailability. It is also a stable complex that does not undergo enzymatic degradation in vivo conditions.

 

APPLICATIONS

  • Enables simultaneous delivery of two different therapeutic molecules to target two different pathways at the disease site.

  • Selectively deliver both anti-cancer and/or nucleic acid molecules to cancer cells.

 

ADVANTAGES

  • Highly stable and easy to synthesize

  • Biocompatible and non-toxic

  • Economic and convenient process

  • The process provides better yields and purity of peptides

  • High entrapment efficiency

  • Controlled release of cargo molecules

 

IP STATUS

The invention has been filed as a PCT application (PCT/IN2021/050170).