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DNA Nanocapsules and Methods for Modular Assembly

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The Novel Technology:

 
The novel technology describes nucleic acid nanostructures and methods for making the same. It includes a modular assembly method of forming DNA nanocapsules. These DNA icosahedral ‘nanocapsules’ are used to successfully encapsulate various substances like label (gold particles) and target moiety (peptide nucleic acids, aptamers) 
 
Applications:
  • To use nanocapsules to encapsulate agents (therapeutic and imaging agents) for drug delivery 
  • To create DNA-protein complexes to mimic viruses and exploit viral entry pathways into cells for delivery of proteins and/or nucleic acids
Advantages:
  • The DNA nanocapsules described here are resistant to nuclease digestion, proving that they are completely ligated and do not have exposed ends
  • DNA nanocapsules have the ability to encapsulate gold nanoparticles, proving that they are functional and can be used for encapsulating other relevant molecules such as drugs, peptides, proteins or nucleic acids
  • Enhances stability of DNA icosahedral nanocapsules 
  • Very large number of identical assemblies could be fabricated simultaneously
  • Enables manufacture of complex nanocapsules by adding functional groups at any desired position
Business Model:
 
The technology is at an early stage with proof-of-concept demonstrating encapsulation of gold particles with the DNA icosahedral structure. Looking for potential licensee(s) to take the technology to the next development stage.
 
Principal Investigator(s): Dr. Yamuna Krishnan, NCBS
 
Invention ID: CMP-020
 
IP Status: Patent Pending
 
Jurisdictions: United States (US)
 
For more details, please write to:
techtransfer @ ccamp.res.in