A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila [Transgenic Fly Facility]

You are here

TitleA sleep-inducing gene, nemuri, links sleep and immune function in Drosophila [Transgenic Fly Facility]
Publication TypeJournal Article
Year of Publication2019
AuthorsToda H, Williams JA, Gulledge M, Sehgal A
Date Published2019 02 01
KeywordsAnimals, Antimicrobial Cationic Peptides, Arousal, Bacterial Infections, Brain, Drosophila melanogaster, Drosophila Proteins, Female, Gain of Function Mutation, Gene Knockout Techniques, Homeostasis, Immune System, Male, Neurons, Sleep

Sleep remains a major mystery of biology. In particular, little is known about the mechanisms that account for the drive to sleep. In an unbiased screen of more than 12,000 lines, we identified a single gene, , that induces sleep. The NEMURI protein is an antimicrobial peptide that can be secreted ectopically to drive prolonged sleep (with resistance to arousal) and to promote survival after infection. Loss of increased arousability during daily sleep and attenuated the acute increase in sleep induced by sleep deprivation or bacterial infection. Conditions that increase sleep drive induced expression of in a small number of fly brain neurons and targeted it to the sleep-promoting, dorsal fan-shaped body. We propose that NEMURI is a bona fide sleep homeostasis factor that is particularly important under conditions of high sleep need; because these conditions include sickness, our findings provide a link between sleep and immune function.

Alternate JournalScience
PubMed ID30705188
PubMed Central IDPMC6505470
Grant List / / Howard Hughes Medical Institute / United States
R01 GM123783 / GM / NIGMS NIH HHS / United States