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In vitro Production of Metabolites from Neem Endophytes

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The Novel Technology: 

 
The invention describes endophytic/epiphytic media formulation for isolation of endophytes (Bacteria and Fungi) from various neem parts or tissues and in vitro production of neem metabolites such as Nimbin, Salanin, Azadirachtin, etc. Currently, neem metabolites are derived from seeds which are season based wherein this technology can help to overcome the issue.
 
Applications:
  • To produce bio-pesticides, antibiotics, bio-fungicides, bio-bactericides, growth promoting hormones and bio-viricides or other metabolites from endophytes
  • To use metabolites purifications from neem endophytes to manage/control of insects and pests of plants and animals 
  • To use metabolites purifications from neem endophytes to manage/control diseases of plants and animals 
  • To use neem endophytes metabolites as the source of antibiotics for human and animal diseases 
  • To use neem endophytes metabolites as source materials to produce important metabolites (eg: anti-cancer)
  • To use endophytic media formulation as relevant assay for screening several medical and agricultural pathogens and pests
  • To use neem endophytic metabolites as source for proteins and enzymes to target diseases
  • To use neem endophytic metabolites as source for enzymes for industrial applications such as fermentation, biofuel (production of ethanol), paper, food, leather curing, etc.,
Advantages:
  • The media provide essential nutrients for growth of neem endophytes
  • The media helps in producing host metabolites such as Nimbin and Salanin
  • Facilitates in mass production and purification of bio-pesticides, antibiotics, bio-fungicides, bio-bactericides and bio-viricides
  • Helps in commercial production of bio-compounds
  • Production of endophytes all through the year compared to natural resource of neem flowering and seeding, which is seasonal
  • Neem media helps in isolating true endophytes from particular plant species
  • Cost effective 
Business Model:
 
Proof of concept has been demonstrated and the technology has been exploited for certain agricultural applications through trial license. Currently seeking industrial partners for collaboration or licensing for further development of this technology. Open for collaborating opportunities to explore endophytes from other tropical plants, trees, medicinal shrubs, etc.
 
Invention ID: CMP-037
 
Principal Investigator(s): Dr. Malali Gowda, Centre for Cellular and Molecular Platforms (C-CAMP)
 
IP Status: Patent Pending
 
Jurisdictions: India (IN) Provisional filed
 
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